If you’ve been prescribed Lariam (mefloquine) for malaria prevention, you probably want to know what can happen after you start the pill. The good news is most people finish their course without big problems. The not‑so‑good news is that some folks do notice headaches, dizziness, or even mood changes. Below we break down the typical complaints, the rarer but serious reactions, and what you can do to stay safe.
Within the first few days, many users report a mild headache or a feeling of “off‑balance.” These usually fade after the body gets used to the drug. Nausea, stomach upset, and loss of appetite are also common – a glass of water with a slice of ginger can help calm the stomach. Some people notice insomnia or vivid dreams. If you’re a night‑owl, try taking the dose earlier in the day to reduce sleep disruption.
A less talked‑about effect is a metallic taste in the mouth. It’s harmless, but it can make food less appealing. Chewing sugar‑free gum or sipping citrus‑flavored drinks often masks the taste. If you’re on any other meds, double‑check with your pharmacist; mefloquine can interact with certain antidepressants and anti‑seizure drugs.
Most side effects are mild, but a few signals mean you should call your doctor right away. Severe anxiety, panic attacks, or sudden mood swings can indicate a neurological reaction. Also watch for hallucinations, ringing in the ears (tinnitus), or loss of coordination. These are rare but serious and need prompt evaluation.
Any sign of an allergic reaction – such as hives, swelling of the face, or trouble breathing – is an emergency. Stop the medication immediately and seek care. Likewise, if you develop persistent vomiting, high fever, or a rash that spreads quickly, get medical attention.
Women who are pregnant or planning to become pregnant should avoid Lariam unless your doctor says it’s absolutely necessary. The drug crosses the placenta and may affect the unborn child.
For most travelers, the benefits of preventing malaria outweigh these risks. Still, if you have a history of depression, anxiety, or seizures, discuss alternatives like atovaquone‑proguanil or doxycycline with your clinician.
To minimize side effects, take Lariam with food, stay well‑hydrated, and avoid alcohol while on the medication. If you miss a dose, take it as soon as you remember unless it’s almost time for the next one – then skip the missed dose and continue with the schedule.
Remember, you’re not alone. Many online forums share real‑world experiences, and talking to a healthcare professional can help you weigh the pros and cons. Keep a simple diary of any symptoms you notice; this makes it easier for your doctor to decide if you should continue, adjust the dose, or switch to another drug.
Bottom line: Lariam can protect you from a dangerous disease, but stay alert to how your body reacts. If side effects are mild, most people finish the regimen without trouble. If anything feels off, don’t wait – reach out to a medical professional. Your health and peace of mind are worth the extra check‑in.
A detailed, side‑by‑side look at Lariam (mefloquine) and its main alternatives, covering efficacy, dosing, side‑effects and how to choose the best malaria prophylaxis.