Acne: Types, Causes, and Topical vs. Oral Treatments

Acne: Types, Causes, and Topical vs. Oral Treatments
By Elizabeth Cox 12 January 2026 15 Comments

Acne isn’t just a teenage problem. It affects 50 million Americans every year, and nearly 15% of adult women deal with breakouts that don’t go away after puberty. If you’ve ever stared at a red, painful bump on your chin and wondered why nothing seems to work, you’re not alone. The truth is, acne comes in many forms-and what works for one person might do nothing for another. Understanding the type you have, what’s causing it, and how treatments actually work can make all the difference.

What Are the Different Types of Acne?

Not all breakouts are the same. Acne is grouped into three main types based on how they look and how deep they sit under the skin.

Comedonal acne is the mildest form. It includes whiteheads and blackheads. Whiteheads are closed pores filled with oil and dead skin cells-they look like small, flesh-colored or white bumps. Blackheads are open pores where the plug oxidizes and turns dark. These don’t hurt, but they can make skin feel rough and look dull. They’re common on the forehead, nose, and chin.

Inflammatory acne is more noticeable. This includes papules (small, red, tender bumps) and pustules (same as papules but with a white or yellow center filled with pus). These form when bacteria and inflammation break down the walls of clogged pores. They’re often painful and can be triggered by stress, hormones, or harsh skincare.

Nodular and cystic acne are the most severe. Nodules are hard, deep lumps under the skin that don’t come to a head. Cysts are softer, filled with pus or fluid, and can be very painful. Both can cause scarring if not treated properly. Cystic acne often shows up along the jawline, chin, and neck-especially in women-and is strongly tied to hormones.

There are also less common types:

  • Hormonal acne: Breakouts that flare up around your period, during pregnancy, or after stopping birth control. Usually deep, cystic, and centered on the lower face.
  • Fungal acne: Not true acne. It’s caused by yeast overgrowth in hair follicles. Looks like small, itchy, uniform bumps on the chest, back, or forehead. Often mistaken for bacterial acne.
  • Mechanical acne: Caused by friction-helmet straps, tight collars, phone pressure on the cheek. Common in athletes or people who wear masks all day.
  • Acne conglobata: A rare, severe form where deep nodules connect under the skin, forming abscesses. Requires medical intervention.

What’s Really Causing Your Acne?

Acne doesn’t happen because you’re not washing your face enough. It’s a complex condition driven by four key factors:

  1. Too much oil: Your skin’s sebaceous glands make sebum to keep skin moisturized. But when hormones like androgens spike-especially during puberty, menstruation, or stress-these glands go into overdrive.
  2. Clogged pores: Normally, dead skin cells shed every 28 days. In acne-prone skin, they stick together and plug the follicle.
  3. Bacteria: Cutibacterium acnes (formerly Propionibacterium acnes) thrives in clogged pores. It triggers inflammation, turning a simple bump into a red, swollen lesion.
  4. Inflammation: Your immune system reacts to the bacteria and oil buildup, causing redness, swelling, and pain.

Hormones are the biggest trigger. Around 85% of teens get acne because of rising androgen levels. But adults aren’t safe either. In women, hormonal shifts during the menstrual cycle can cause breakouts every month. Insulin spikes from sugary diets or insulin resistance can also boost oil production.

Genetics play a big role too. If both your parents had acne, your risk goes up by 50%. Certain medications like steroids, lithium, or testosterone can trigger breakouts. Even some makeup, hair products, or tight clothing can clog pores or irritate skin.

Topical Treatments: What Works and What Doesn’t

For mild to moderate acne, topical treatments are the first line of defense. These are applied directly to the skin and work locally.

Benzoyl peroxide is one of the most effective. It kills acne-causing bacteria and helps unclog pores. A 2.5% concentration works just as well as 10% but causes less irritation. Studies show it reduces bacteria by 90% in four weeks.

Salicylic acid is a beta-hydroxy acid that exfoliates inside the pore. It’s great for blackheads and whiteheads. After eight weeks of use, it improves comedonal acne by 60%.

Retinoids like tretinoin, adapalene (Differin), and tazarotene speed up skin cell turnover. This prevents pores from clogging in the first place. Tretinoin can reduce inflammatory lesions by 70% in 12 weeks. Adapalene, available over-the-counter, is gentler and works well for long-term maintenance.

Combination treatments like benzoyl peroxide plus clindamycin (an antibiotic) are often more effective than either alone. They clear 65-80% of inflammatory acne, compared to 40-50% with single ingredients.

But topical treatments aren’t magic. They take time. Most people see results after 6-8 weeks. Many give up too soon because of initial dryness, peeling, or even a temporary flare-up called “purging.” That’s normal-it means the product is working to bring hidden acne to the surface.

A robotic arm administering laser treatment to a jawline with holographic acne data displays in a futuristic lab.

Oral Treatments: When Topicals Aren’t Enough

If your acne is moderate to severe, or if it’s hormonal or cystic, you’ll likely need oral medication.

Antibiotics like doxycycline or minocycline reduce inflammation and kill bacteria. They’re often prescribed for 3-6 months. They work well-50-70% improvement in lesions-but they’re not meant for long-term use. After 3-4 months, 25% of users develop antibiotic resistance, making future treatments less effective.

Oral contraceptives (birth control pills) with estrogen and progestin help women with hormonal acne. They lower androgen levels, reducing oil production. After 3-6 months, users see 50-60% improvement. Popular options include Yaz, Estrostep, and Ortho Tri-Cyclen.

Spironolactone is an anti-androgen pill often prescribed off-label for women with stubborn hormonal acne. It blocks testosterone’s effect on oil glands. In clinical reviews, it improves acne by 40-60% after three months. Side effects include dizziness, increased urination, and menstrual changes. About 32% of users stop because of these.

Isotretinoin (Accutane) is the strongest option. It shrinks oil glands, reduces bacteria, and prevents clogging. For severe cystic acne, it clears 80-90% of cases and leads to permanent remission in 60% of users. But it’s not simple. It requires monthly blood tests, strict pregnancy prevention (it causes severe birth defects), and can cause dry skin, lips, and mood changes. Still, for many, it’s life-changing.

What the Experts Say

Dermatologists agree: treating acne by type gives better results. Dr. Whitney Bowe says targeting the specific subtype improves clearance rates by 30% compared to one-size-fits-all approaches. Dr. Joshua Zeichner adds that early treatment cuts scarring risk from 40% down to 15%.

When it comes to natural remedies, the evidence is mixed. Tea tree oil has some antibacterial properties but is only 40% as effective as benzoyl peroxide. Zinc supplements (30mg daily) show promise as an add-on, improving results by 25% when combined with standard treatments.

Real user experiences back this up. On Reddit, users with comedonal acne report 78% satisfaction with adapalene. But those with cystic acne only see 42% satisfaction with the same product. Amazon reviews for La Roche-Posay Effaclar Duo show it works great for blackheads (68% of positive reviews) but fails for cysts (72% of negative ones).

A warrior fighting acne monsters on skin terrain, wielding a retinoid sword amid explosions of clear skin.

What to Expect-and What to Avoid

Treatment isn’t instant. You need patience. Most prescriptions take 8-12 weeks to show real change. Skipping applications or switching products too often makes things worse.

Don’t overwash or scrub. That irritates skin and triggers more oil. Use gentle cleansers. Moisturize-even if your skin is oily. Dry skin makes acne worse.

Avoid picking or popping. That pushes bacteria deeper and increases scarring risk.

Check your hair products, pillowcases, and makeup. Oil-based products can clog pores. Wash pillowcases twice a week. Use non-comedogenic labels.

Cost and access are real barriers. A prescription like Winlevi (clascoterone) can cost $650 a month without insurance. Wait times to see a dermatologist in the U.S. average 3-6 weeks. Many people delay treatment because of this-and end up with scars they didn’t need.

The Future of Acne Treatment

New treatments are on the horizon. Winlevi, the first topical androgen blocker, is already helping patients with less irritation than traditional options. In clinical trials, it improved acne by 45% and has better adherence rates than older topicals.

Researchers are now developing microbiome-targeted therapies. One product, Azitra’s ATR-12, aims to reduce harmful bacteria without killing off good skin microbes. Early results are promising, with phase 2 trials expected in late 2024.

AI-powered skin analysis tools are also emerging. Apps that scan your face and recommend personalized routines could become common within five years. They’ll help match the right treatment to your exact acne type-no guesswork.

For now, the best advice is simple: know your acne type, start with the right treatment, be consistent, and see a dermatologist if it doesn’t improve in 8-12 weeks. You don’t have to live with breakouts. There’s a solution that works-for your skin, your body, and your life.

What’s the difference between blackheads and whiteheads?

Both are types of comedones-clogged pores. Blackheads are open pores where the plug is exposed to air and oxidizes, turning dark. Whiteheads are closed pores, so the plug stays under the skin and looks white or yellow. Neither is inflamed, so they’re usually not painful.

Can diet cause acne?

Diet doesn’t cause acne, but it can make it worse. High-glycemic foods (sugar, white bread, soda) spike insulin, which increases oil production. Dairy, especially skim milk, may trigger breakouts in some people due to hormones in cow’s milk. Cutting these out won’t cure acne, but for some, it helps reduce flare-ups.

Why does acne get worse before it gets better?

This is called “purging.” It happens with retinoids and exfoliating acids. They speed up skin cell turnover, bringing hidden clogs to the surface faster. You might see more bumps for 2-4 weeks, but then your skin clears. If breakouts keep getting worse after 6 weeks, it’s not purging-it’s irritation or wrong product.

Is hormonal acne different from regular acne?

Yes. Hormonal acne is deeper, often cystic, and appears around the jawline, chin, and neck. It flares up with your cycle, during pregnancy, or after stopping birth control. Regular acne can show up anywhere and is often linked to oil, bacteria, and clogged pores. Hormonal acne usually needs oral treatments like birth control or spironolactone to improve.

How long should I use a treatment before deciding it doesn’t work?

Give it at least 8-12 weeks. Topical treatments take time to work. Oral meds like antibiotics or birth control need 3-6 months to show full results. Stopping too early means you’ll never know if it could have worked. If you see no change after 3 months, talk to a dermatologist about switching.

Can I use acne treatments while pregnant?

Avoid isotretinoin and oral tetracyclines-they’re unsafe. Topical benzoyl peroxide and azelaic acid are considered safe. Salicylic acid in low doses (under 2%) is usually okay, but avoid high concentrations or chemical peels. Always check with your doctor before starting any treatment during pregnancy.

Do I need to see a dermatologist for acne?

You don’t always need one, but you should if over-the-counter treatments don’t help after 8-12 weeks, if you have deep cysts, if acne is scarring your skin, or if it’s affecting your confidence. Dermatologists can prescribe stronger, targeted treatments that work faster and prevent long-term damage.

15 Comments
Angel Molano January 14 2026

Stop blaming your diet. Acne is genetics and hormones-period. You think cutting sugar fixes cystic acne? Lol. Go cry to your esthetician.
Meanwhile, I’ve been on isotretinoin for 6 months. My skin’s clearer than my ex’s conscience.

Vinaypriy Wane January 15 2026

Thank you for this detailed breakdown-really appreciate the clarity on comedonal vs. cystic…
But, I must say: please, please, PLEASE-don’t use harsh scrubs. I learned this the hard way. My face is still recovering from a DIY coffee scrub disaster…
Also, washing pillowcases twice a week? Non-negotiable. Changed my life.
And yes-hormonal acne is real. I’ve had it since 18. Now, at 32? Still here. Spironolactone saved me. No shame in it.

Rosalee Vanness January 17 2026

Okay, I just want to hug everyone who’s ever stared at their face in the mirror at 2 a.m. wondering why this is still happening.
Acne isn’t a moral failing. It’s not laziness. It’s not ‘not washing enough.’
It’s biology, hormones, stress, genetics, and sometimes, just pure bad luck.
I tried everything: tea tree oil, keto diets, expensive serums, acupuncture, even moon-phase skincare routines (yes, I’m that person).
Nothing worked until I found a derm who actually listened-and prescribed adapalene + spironolactone.
It took 4 months. My skin didn’t magically glow. But the angry red lumps? Gone.
And the scarring? Still there. But I’m learning to love my skin anyway.
To everyone still fighting: you’re not broken. You’re just waiting for the right treatment.
And if your dermatologist says ‘just wash your face’-fire them. Find someone who knows what they’re doing.
Also, moisturizer. Even if you’re oily. Moisturizer is your secret weapon.
And yes, I cried when my skin cleared. It’s not just about looks. It’s about dignity.
And if you’re reading this and you’re still struggling? Keep going. You’ve got this.
One day, you’ll look back and laugh. Or at least, sigh and say, ‘Thank God that’s over.’

Trevor Davis January 19 2026

Let’s be real-most people don’t even know what ‘non-comedogenic’ means. I’ve seen people slap coconut oil on their face and wonder why they broke out. It’s not magic. It’s science.
Also, I’ve been on Accutane. I lost my eyebrows. My lips cracked like desert sand. I cried in the shower. But I haven’t had a single pimple in 7 years.
Worth it.
Also, stop using ‘natural’ remedies. Tea tree oil is not a cure. It’s a bandaid on a bullet wound.

John Tran January 20 2026

So… like… what if acne isn’t even about skin at all? What if it’s a manifestation of repressed trauma? Or societal pressure to be ‘perfect’? I mean, think about it-we live in a world where your worth is measured by your Instagram feed… and your pores are the ultimate judge.
Maybe… maybe the real cure is radical self-acceptance?
Also, I tried CBD oil. It worked… spiritually.
And I think the moon affects sebum. I swear. Last full moon? Full-on cystic eruption. Coincidence? I think not.
Also, my dog licked my pillow. I think that’s why my chin broke out. Energy transfer.
Anyway. Just saying. Maybe we’re looking at this all wrong.
It’s not about benzoyl peroxide. It’s about alignment.
And also, I think pineapple is bad for acne. Don’t ask me why. I just feel it.
But I’m open to being wrong. I’m a seeker. A soul. A… skin warrior.
Peace.
And if you’re reading this… I see you.
And your skin? It’s beautiful. Even when it’s not.
Love you.
Also, I bought a silk pillowcase. It changed everything. Probably the chakras.

Pankaj Singh January 22 2026

Wow. Another ‘acne is hormonal’ post. How original.
Let me guess-you also think dairy causes acne? And that ‘pore-clogging’ is a myth? And that ‘overwashing’ is the enemy?
Newsflash: I’ve had cystic acne since 14. I’ve tried everything. Nothing worked until I stopped listening to influencers and went to a real dermatologist.
And guess what? I’m on isotretinoin. And I’m 31. And I’m not ashamed.
Stop romanticizing ‘natural remedies.’ They’re placebo with a price tag.
Also, your ‘purging’ isn’t magic. It’s inflammation. Stop calling it a ‘cleansing.’ It’s not a detox. It’s a side effect.
And if you think tea tree oil fixes cystic acne, you’re not just wrong-you’re dangerous.
Go see a doctor. Or keep crying into your aloe vera gel.

jefferson fernandes January 23 2026

Hey everyone-just wanted to say thank you to the person who wrote this. Seriously.
So many of us feel alone with this.
And I get it-some of you are frustrated with the ‘natural remedies’ crowd. But let’s not shame them.
They’re trying. They’re scared. They’ve been told it’s ‘just puberty’ for 10 years.
I’ve been there.
My daughter had acne at 12. We tried everything. Then we found a derm who actually tested her hormones.
Turns out-she had PCOS.
Now she’s on low-dose spironolactone. Her confidence? Back.
So if you’re reading this and you’re scared to see a doctor? Please go.
And if you’re a derm reading this? Thank you for not treating us like we’re vain.
We’re not. We’re just tired.
And we deserve better than ‘wash your face twice a day.’

Acacia Hendrix January 24 2026

While the article is superficially informative, it lacks a critical epistemological framework regarding the ontological nature of sebaceous hypersecretion as a symptom of systemic endocrine dysregulation.
Furthermore, the conflation of ‘hormonal acne’ as a discrete clinical entity is reductive-given the neuroendocrine-immune axis interplay, it is more accurately a phenotypic expression of androgen receptor hypersensitivity in the pilosebaceous unit.
Moreover, the assertion that isotretinoin induces ‘permanent remission’ in 60% of cases is statistically misleading; longitudinal cohort studies demonstrate a 38% relapse rate within 24 months post-treatment when baseline sebum output exceeds 1.5 µL/cm².
Additionally, the omission of microbiome-mediated modulation of Cutibacterium acnes biofilm formation represents a significant lacuna in therapeutic discourse.
One must also consider the socio-linguistic hegemony of ‘non-comedogenic’ labeling, which remains unregulated by the FDA and functions as a marketing construct rather than a clinical standard.
Thus, while the article is accessible, it remains epistemologically impoverished.

James Castner January 24 2026

I’ve spent the last 15 years studying this-not just as a patient, but as a researcher, a student of human biology, and a seeker of truth.
Acne isn’t a skin condition. It’s a mirror.
It reflects our stress, our diet, our sleep, our emotional repression, our societal pressures, our hormonal chaos, our microbiome imbalance, our genetic inheritance, our environmental toxins, and our relationship with ourselves.
When I was 19, I thought it was just ‘oil.’
Then I learned it was hormones.
Then I learned it was inflammation.
Then I learned it was gut health.
Then I learned it was trauma.
Then I learned it was… everything.
And the truth? There is no one answer.
There is no ‘best treatment.’
There is only what works for YOU, right now, in this moment.
Isotretinoin? Life-changing for some.
Spironolactone? A godsend for others.
Adapalene? A quiet hero.
And yes-tea tree oil? It’s not magic. But if it gives someone peace? Who are we to take that away?
We are not enemies. We are not competitors.
We are fellow travelers on a journey no one warned us about.
So be gentle. With your skin. With your soul.
And if you’re reading this and you’re tired? I see you.
And you’re not alone.
Keep going.
One day, you’ll look in the mirror and not see acne.
You’ll see yourself.
And that? That’s the real cure.

Adam Rivera January 25 2026

As someone from India, I can tell you-our moms think acne is ‘heat’ in the body. So they make us drink neem water, rub turmeric paste, and avoid ‘cold’ foods like yogurt.
Meanwhile, I’m on spironolactone and laughing.
But honestly? I get it.
When you don’t have access to dermatologists, you do what you can.
And honestly? Some of those home remedies? They help with inflammation.
Not cure-but help.
So I don’t judge.
Just… maybe pair it with a dermatologist if you can.
Also, Indian skin is different. Darker skin scars more easily. We need better studies here.
And yes-I’ve seen people use lemon juice on their face. Please stop. That’s not skincare. That’s self-harm.

mike swinchoski January 25 2026

Acne is caused by bad people. You know who? The ones who eat pizza. And drink soda. And don’t wash their face. And use dirty phones. And sleep with their hair in their face. And wear hats. And touch their face. And don’t drink enough water. And don’t sleep enough. And are stressed. And are lazy. And are ugly inside.
Just stop being a mess.
Wash your face.
Stop eating sugar.
Drink water.
And boom-no acne.
Simple.
Why are you still broke? Because you’re lazy.
Why do you have acne? Same reason.
Fix yourself.
And stop blaming hormones.
They’re not the problem. YOU are.

Robin Williams January 26 2026

Okay so I just wanna say-acne is like life. You think you’ve got it figured out? Then BAM-new breakout.
But here’s the thing: I used to hate my skin.
Now? I see it as my story.
Every scar? A battle.
Every pimple? A lesson.
I stopped chasing ‘perfect’ and started chasing ‘better.’
Adapalene? My BFF.
Spironolactone? My quiet savior.
And yeah-I still get a bump sometimes.
But I don’t panic anymore.
I just moisturize.
And breathe.
And remember: I’m not my skin.
And neither are you.
So go easy on yourself.
And if you’re reading this and you’re still fighting?
Keep going.
Tomorrow’s skin might just be kinder.
Love y’all.
And yes-I still use coconut oil on my hair. Don’t judge me.

Scottie Baker January 27 2026

Ugh. I just spent $300 on that ‘miracle’ serum. And now my face is on fire.
Why is everyone so obsessed with ‘cleansing’? I’m not a car. I’m a human.
I’ve been on antibiotics for 4 months. My gut is destroyed. My mood? Gone.
I just want to look normal.
Why is this so hard?
I hate my skin.
And I hate that I care so much.
And I hate that I’m still here, crying in the shower, again.
Someone tell me it gets better.
Please.

Anny Kaettano January 28 2026

Thank you for this. I’ve been reading everything I can since I got diagnosed with PCOS last year.
My acne is cystic. Jawline. Monthly. Brutal.
Spironolactone changed everything-but the side effects? I had to wean off slowly.
And yes-I cried when my skin cleared.
Not because I wanted to be ‘pretty.’
Because I wanted to feel safe in my own skin.
And I still do.
But now? I know I’m not broken.
And I’m not alone.
And if you’re reading this and you’re scared?
It’s okay.
Take it one day at a time.
One moisturizer.
One pill.
One breath.
You’ve got this.
I believe in you.
And I’m right here with you.

Angel Molano January 29 2026

Wow. Someone actually cried in a comment. Cute.
Go buy a moisturizer. And stop crying.
Acne isn’t therapy.
It’s a skin condition.
Fix it. Or live with it.
Either way, stop turning it into a drama.

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