Mefloquine – Quick Guide for Travelers and Patients

If you’re heading to a region where malaria is a risk, you’ve probably heard of mefloquine. It’s an oral medication that’s been used for decades to keep the malaria parasite away. In plain terms, you take a pill before, during, and after your trip, and it works behind the scenes to stop the infection before it starts.

Most doctors prescribe a single dose of 250 mg once a week. That means you pop a pill on day 1, then again on day 8, day 15, and so on, continuing for four weeks after you leave the malaria‑endemic area. The schedule sounds strict, but sticking to it is the best way to stay protected.

How Mefloquine Works

Mefloquine targets the parasite while it’s still in the blood. It disrupts the parasite’s ability to build its own membrane, which essentially kills it before it can settle in the liver. This action is different from some newer drugs that focus on the liver stage, so mefloquine works well for many strains of Plasmodium that cause malaria.

The drug is absorbed quickly, reaching its peak level in about 8‑12 hours. Because it stays in your system for a long time, the once‑a‑week dosing works – you don’t need daily pills.

Common Concerns & Safety Tips

Like any medicine, mefloquine can cause side effects. The most frequent ones are mild: nausea, headache, dizziness, or trouble sleeping. These usually fade after a few days. Some people report vivid dreams – nothing dangerous, just a bit unsettling.

Rarely, the drug can affect the brain or mood, leading to anxiety, depression, or even hallucinations. If you notice any sudden change in mood or thoughts, stop the drug and get medical help right away.

People with a history of seizures, psychiatric conditions, or certain heart problems should avoid mefloquine unless a doctor says it’s safe. Always share your full medical history before starting the regimen.

To reduce stomach upset, take the pill with food or a full glass of water. If you experience nausea, try a light snack before the dose. Staying hydrated helps the body process the medication.

Travelers often wonder whether they need an extra dose after returning. The rule of thumb is to finish the weekly dose for four weeks after leaving the endemic zone. Skipping this follow‑up can leave you vulnerable to a late‑onset infection.

If you’re pregnant or planning to become pregnant, talk to your doctor. Mefloquine is generally considered safe in the second and third trimesters, but the first trimester carries more uncertainty.

Finally, store your pills in a cool, dry place away from children. Keep the original packaging so you can check the expiration date before each dose.

Bottom line: mefloquine is a reliable, once‑a‑week guard against malaria when you follow the schedule and watch for side effects. Talk to your healthcare provider, read the patient leaflet, and you’ll be set for a safer trip.